Association of Primary Myeloperoxidase Deficiency and Myeloproliferative Neoplasm

Association of primary myeloperoxidase deficiency and myeloproliferative neoplasm.

We report a 63-year-old woman with myeloproliferative neoplasm (MPN), who presented with inflammatory involvement of the skin. The white cell count was 31,800/μL and the platelet count was 709×10/μL. The positivity of neutrophil alkaline phosphatase was 100% and the score was 281. The bone marrow was hypercellular with enlarged megakaryocytes with mature cytoplasm and multilobulated nuclei (Pic...

The possible association of monoclonal gammopathy of undetermined significance and JAK2-V617F positive chronic myeloproliferative neoplasm.

Correspondence to: Prof. Toni Valković, MD, PhD, department of hematology, rijeka university hospital Center, Krešimirova 42, hr-51000 rijeka, Croatia E-mail: [email protected] received february 4, 2013, accepted march 31, 2014 dear Editor, i have noticed a possibly coincidental, but intriguing issue, previously investigated by some authors, which i would like to re-actualize and share with hemat...

Hereditary myeloperoxidase deficiency.

Subjects with neutrophil myeloperoxidase (MPO) deficiency have been rarely reported. In part this may be due to the lack of a simple screening technique that would detect them. With the routine use of a cytochemical leukocyte differential counter that employs MPO stains, over a 40-mo a period 8 unrelated probands with partial MPO-deficiency and one with complete deficiency were identified. Fami...

Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common pathways for skin inflammation encompass overexpression of thymic stromal lymphopo...

Low-dose methotrexate in myeloproliferative neoplasm models.